T Cell Anergy: Where It's LAT

Molecular regulation of T-cell anergy.

The activation of T cells is tightly controlled by many positive and negative regulatory processes. This fine-tuning allows productive immunity to pathogens while minimizing the risk of autoimmunity. One negative regulatory mechanism is clonal anergy, which is a hyporesponsive state that occurs when T cells are activated through the T-cell antigen receptor in the absence of appropriate co-stimu...

The Balance Between Donor T Cell Anergy

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.

The linker molecule LAT is a critical substrate of the tyrosine kinases activated upon TCR engagement. Phosphorylated LAT binds Grb2, PLC-gamma1, and other signaling molecules. We demonstrate that human LAT is palmitoylated and that palmitoylated LAT predominantly localizes into glycolipid-enriched microdomains (GEMs). Although the LAT transmembrane domain is sufficient for membrane localizatio...

Biochemical and functional characterization of Fyn-PAG association and its role in T-cell anergy

ACKNOWLEDGEMENT Acknowledgement I am deeply thankful to my mentor, Dr. Jonathan A. Lindquist, for his invaluable scientific advice and professional guidance that lead me throughout the whole project. He was more than a simple supervisor of my PhD thesis; he really took care of my life, not only professionally but also privately. Not only did he gave me all the knowledge what was in his might, b...

CD8+ memory T-cell inflation renders compromised CD4+ T-cell-dependent CD8+ T-cell immunity via naïve T-cell anergy

Whether inflation of CD8+ memory T (mT) cells, which is often derived from repeated prime-boost vaccinations or chronic viral infections in the elderly, would affect late CD8+ T-cell immunity is a long-standing paradox. We have previously established an animal model with mT-cell inflation by transferring ConA-stimulated monoclonal CD8+ T cells derived from Ova-specific T-cell-receptor transgeni...